I have a 2010 Honda Odyssey EX with 114,000 miles. We have noticed a problem that occurs only above 60 mph. It is a shudder that feels like it is underneath the drivers seat. It can also be felt by the front passenger. The shudder occurs infrequently, for example once or twice every ten to twenty miles on the interstate, and sometimes not at all. I think I read it may be a driveshaft problem. It was purchased in April 2016. Since the purchase, it has had two (yes, two!) engine replacements. After the second replacement, the dealership also noticed there was a problem with the steering and replaced the steering rack. We recently put new tires on the van and had a wheel alignment, along with replacing the drivers side front wheel bearings. This has not fixed the problem with the intermittent shudder. The van drives smoothly otherwise.