Our Odyssey is a 2004. We have 3 kids and they are all still in car seats or boosters. After trying several arrangements we have found one we really like. The toddler's seat is driver side, 2nd row. The older two are in the outside positions of the 3rd row. They keep a stash of toys between them in the middle position.
The best part for us is that we decided to completely remove the 2nd row chair on the passenger side and leave it in the garage. This gives us a very large open area in the middle of the van that is wonderful for helping kids with seatbelts, etc. without having to climb over something. It also makes it easy to load the toddler in the rain (he wiggles a lot) without getting wet yourself, and it helps with passing toys, snacks, etc. to the back row from the front. If we want, we can also sit a cooler in that middle area and strap it to the unused chair points on the floor. That makes lunches on long trips really easy.
We almost never have passengers other than dad+mom+3 kids, so it works great for us.