It shouldn't have a negative affect, on actual fuel economy or acceleration and in fact will probably help - the PAX system wheels are heavier than conventional wheels.Hi theStig,
Last week, I depaxed my 07 Touring with 2020 Odyssey stock wheels 235-60-18 and Firestone tires.
The wheels look good and the ride feels a lot smoother than the original touring tires.
Took a 240 mile trip this weekend and it worked fine, no issues so far (fingers crossed).
But I believe, with the larger heavier tires fuel economy will take a small hit and also acceleration on the highway.
Good luck with the depaxing
Your wheel / tire configuration has a larger diameter than what was on the car originally though, and so you will travel ~3.8% further than what the odometer reads (~103.8 miles for every 100 registered by the odometer) and thus you would need to adjust the miles traveled to calculate the actual fuel economy.