well, the earlier 99-00 models came with 215/65/16's and 01-04 came with 225/60/16's. Although the 225's may be just a hair wider, the overall diameter of the two sizes should be pretty close to the same. So to answer your question, no it shouldn't cause you any issues. I prefer the 225's in the front.
If yours is a 1999, you have a single speed sensor, specifically the countershaft speed sensor from the tranny to serve the speedometer, and I think the cruise control as well. 215 or 225 won't matter on the front end, just somewhat different speedometer readings for a given true groundspeed.