Just hit the 250K mark, yes with the original tranny so it can be done.
1999 Odyssey LX
Bought new in February of 1999 from Hennessy Honda in Woodstock, GA I had to pay $500 over sticker which at the time was a good deal
Parts I've replaced or repaired (as far as I can remember a least)
Many sets of tires
A bazillion sets of front brake pads
3 sets of rotors
1 front brake caliper
Replaced all belts, timing chain, water pump, etc - twice
2 sets of spark plugs
Many air/cabin filters
Few dash lights
Both sliding door handles
Just changed one of the sliding door latch mechanism
Repaired the rear wiper (shaft had rusted - took apart, cleaned and re-installed)
Air bag control module
Both real window motors - under warranty
Both O2 sensors
2 front windshields
1 rear windshield (don't ask)
A few tie rod ends
Sway bar control links
1 front wheel bearing (I did not do this repair)
The only major repair was when I replaced the PS rack and pump, which most of that I did myself.
Currently needs a rear wheel bearing replaced, have the parts just need to find the time. I'm going to change everything on both sides while I have it apart. All new brake parts and rear shocks.
Still getting 23MPG on the highway and does not burn a drop of oil between changes.