Mileage?
How old battery?
Live in rust belt?
Battery terminals clean and tight?

 

72,000 miles. Battery is less than 4 months old with clean and tight terminals. Live in Alabama.

 

Get codes read somewhere.
Sounds electrical.
Chewed up wires?
Odd.
Noise prior concerning.

That's all I got.

Good luck

ETA; I lied. Found this.
Does any of this sound familiar?
Fuel pump; Safety Recall;

http://www.urvi.net/forumfiles/SB/A21-026.PDF

Have you perused these TSB's

2019 Honda Odyssey Technical Service Bulletins

Here is what is required to be able to access the Honda/Acura links: 1. Open this Honda eStore link: Honda online store : 2019 Odyssey Accessory installation (DIY) instructions 2. Open any Honda/Acura link Note: The Honda eStore link allows access to the Honda/Acura links for ~ 1 day...

www.odyclub.com

Enter Vin for recall check;

Recalls | NHTSA

Use our VIN lookup tool to check for recalls on your car, or search by make and model. Also, get recall information on car seats, tires and equipment.

www.nhtsa.gov

Recall Information for Safety & Defects | Honda Owners Site

Honda places a high priority on providing safety and quality products. Search VIN or Model/Year for recall information on Honda cars, crossovers and SUVs.

owners.honda.com

 

@DPaulk
Don't say that it cannot be in the transmission, as the TCU (Transmission Control Unit -motherboard) talks to the engine controller and can tell it too not raise the RPM's during that time, for instance would be when the transmission would be shifting between drive-gears to lowers it's RPM by 400 RPMS to shift smother. I am not saying that is what the problem is, but at the same time it could be the transmission as well as any other component on the engine.

 

Put " why does my Honda Odyssey hesitate when I accelerate? " in the search box of Google etc. for some possible solutions. Or something similar.
I am surprised more members haven't responded as I'm pretty sure you aren't the only one with this problem.
Do get codes read just in case there is one.
Buffalo4

 

Are there any outstanding TSBs or recalls on your VIN?

 

Check out this search link to see if anything might fit the problems you are having.

Google Search

Here is another link:

Hesitation on acceleration

My wife and I got our first Honda Odyssey in Feb. 2020, a 2019 EX-L with navi which had about 50k miles already. We're having an intermittent issue with the accelerator and the dealer doesn't seem to even believe us, much less have any idea what might be causing this. I know we're not crazy...

www.odyclub.com

Buffalo4

 

I have the exact same issue, and the noise comes from the front driver side. Full loss of acceleration for 2-4 seconds with the gas peddle depressed.

 

@DPaulk - did you find any resolution for this problem? My van is making a noise from the front driver side and losing acceleration for 2-4 seconds usually around 50-70km/hr. Rpms go to 1000. Seems to be happening more frequently now- once per drive usually.

 

@bradmcfo
I would attempt cleaning the throttle body. Not a difficult process. Do a advanced search here in the 2018 Forum, use user Bandit400 and search.